Optimation of Nanocream 3,4-dimethoxychalcone as UVA Protection Agent Used Simplex Lattice Design Method
Keywords:
3,4-dimetoksikalkon, sunscreen, proteksi-UVA, nanokrim, design-expert
Abstract
3,4-dimethoxychalcone (3,4-DMT) is a chalcone derivative can be used as a UVA-protection agent but its insolubility in water (log-P 3.84). Therefore, an appropriate delivery system is needed that can increase the solubility and transport of 3.4 DMT through the skin layer. The nanocream formulation was chosen to make chemical sunscreen preparations suitable for water insoluble ingredients. This study aims to obtain the optimal composition of 3,4-DMT in a nanocream formula. Nanocream formulation was carried out using the simplex lattice design method. VCO was used as the oil phase with a mixture of tween 80 and span 80 (Smix) which was mixed using a high-energy-emulsification method. Physical test of nanocream such as pH, spreadibility, viscosity, adhesion, freeze thaw showed result good result and particle size > 200 nm, zeta potential ± 30 mV, PDI < 1; drug content 94.02%-94.90%. Data analysis for all measurements used ANOVA statistical analysis.
References
Abdulkarim, M.F. et al. 2011. Formulation and characterization of palm oil esters based nano-cream for topical delivery of piroxicam. International Journal of Drug Delivery, pp. 2: 287–298.
Ali, S. and Yosipovitch, G. 2013. Skin pH: From Basic SciencE to Basic Skin Care. Acta Dermato Venereologica, pp. 93: 261–267.
Asfour, M.H., Kassem, A.A. & Salama, A. 2019. Topical nanostructured lipid carriers/inorganic sunscreen combination for alleviation of all-trans retinoic acid-induced photosensitivity: Box-Behnken design optimization, in vitro and in vivo evaluation. European Journal of Pharmaceutical Sciences, 134, pp. 219–232. doi:10.1016/j.ejps.2019.04.019.
Atmanto, D. 2019. Effectiveness of utilizing VCO oil and castor oil on natural creams for dry skin treatment due to environmental factors. Journal of Physics: Conference Series, p. 1402: 022093.
ChemSpider. 2019. 3,4-dimethoxychalcone. Available at: url: http://www.chemspider.com/Chemical-Structure.4510680.html?rid=f1f6ec7c-f17f-4fd6-9de6-f1440f076ca6
Dewi, R. and Anwar, E. 2014. Uji Stabilitas Fisik Formula Krim yang Mengandung Ekstrak Kacang Kedelai (Glycine max). Pharmaceutical Sciences and Research, pp. 1: 194–208.
El-Badry, M. et al. 2014. Solubility and Dissolution Enhancement of Tadalafil Using Self-Nanoemulsifying Drug Delivery System. Journal of Oleo Science, pp. 63: 567–576.
Fatmasari, E. and Zulkarnain, A.K. 2021. 3,4‑dimethoxychalcone novel ultraviolet‑A protection factor in conventional sunscreen cream. JAPTR, pp. 279–284. doi:10.4103/japtr.JAPTR.
Grag, A., Anggarwal, D. and Garg, S. 2002. Spreading of Semisolid Formulations. North America: Pharmaceutical Technology, pp. 26(9): 84-105,.
Jain, P. et al. 2017. Nanostructure lipid carriers: A modish contrivance to overcome the ultraviolet effects. Egyptian Journal of Basic and Applied Sciences, pp. 4: 89–100.
Jaiswal, M., Dudhe, R. & Sharma, P.K. 2015. Nanoemulsion: an advanced mode of drug delivery system. Biotech, pp. 5:123-127.
Jiwrajka, M. et al. 2016. The Plant-Derived Chalcone 2,2′,5′-Trihydroxychalcone Provides Neuroprotection against Toll-Like Receptor 4 Triggered Inflammation in Microglia. Oxidative Medicine and Cellular Longevity, pp. 1–10.
Jumina, J. et al. 2019. Synthesis and preliminary evaluation of several chalcone derivatives as sunscreen compounds. Chemistry Journal of Moldova, 14(2), pp. 90–96. doi:10.19261/cjm.2019.624.
Mohammadi, S.M. et al. 2018. Effects of amount of excess solid, the type of stirring and sedimentation time on solubility of sodium phenytoin and lamotrigine. ADMET & DMPK, p. 10.
Osterwalder, U. and Herzog, B. 2010. The long way towards the ideal sunscreen - Where we stand and what still needs to be done. Photochemical and Photobiological Sciences, 9(4), pp. 470–481. doi:10.1039/b9pp00178f.
Rahmi, D., Yunilawati, R. & Ratnawati, E. 2013. Pengaruh Nano Pratikel Terhadap Aktifitas Antiageing pada Krim. Jurnal Sains Materi Indonesia, pp. 14 No.3: 235–238.
Ratri, S.A. 2018. Synthesis and Activity Test Of Chalcone Derivates As Broad Spectrum Sunscreen Agent And Filter Phototheraphy Agent. Universitas Gadjah Mada.
Reis Mansur, M.C.P.P. et al. 2016. In vitro and in vivo evaluation of efficacy and safety of photoprotective formulations containing antioxidant extracts. Revista Brasileira de Farmacognosia, 26(2), pp. 251–258. doi:10.1016/j.bjp.2015.11.006.
Singh, Y. et al. 2017. Nanoemulsion: Concepts, development and applications in drug delivery. Journal of Controlled Release, pp. 252: 28–49.
Sopyan, I., Gozali, D. & Paramudya, E. 2020. Formulation and Stability Testing of Griseovulfin Microemulsion. Indonesian Journal of Pharmaceutics, pp. 34–42.
Swastika, A., Mufrod & Purwanto. 2013. Antioxidant Activity of Cream Dosage Form of Tomato Extract (Solanum lycopersicum L.). Traditional Medicine Journal, pp. 18(3): 132–140.
Tou, K.A.S. et al. 2019. Influence of omega fatty acids on skin permeation of a coenzyme Q10 nanoemulsion cream formulation: characterization, in silico and ex vivo determination. Drug Development and Industrial Pharmacy, pp. 45: 1451–1458.
Wasitaatmadja, S. 1997. Penuntun Ilmu Kosmetik Medik. Jakarta: UI Press.
Winter, E., Pizzol, C., Locatelli, C., et al. 2014. In-vitro and in-vivo Effects of Free and Chalcones-Loaded Nanoemulsions: Insights and Challenges in Targeted Cancer Chemotherapies. International Journal of Environmental Research and Public Health, pp. 11: 10016–10035.
Zainol, N., Ming, T. & Darwis, Y. 2015. Development and characterization of cinnamon leaf oil nanocream for topical application. Indian Journal of Pharmaceutical Sciences, p. 77: 422.
Ali, S. and Yosipovitch, G. 2013. Skin pH: From Basic SciencE to Basic Skin Care. Acta Dermato Venereologica, pp. 93: 261–267.
Asfour, M.H., Kassem, A.A. & Salama, A. 2019. Topical nanostructured lipid carriers/inorganic sunscreen combination for alleviation of all-trans retinoic acid-induced photosensitivity: Box-Behnken design optimization, in vitro and in vivo evaluation. European Journal of Pharmaceutical Sciences, 134, pp. 219–232. doi:10.1016/j.ejps.2019.04.019.
Atmanto, D. 2019. Effectiveness of utilizing VCO oil and castor oil on natural creams for dry skin treatment due to environmental factors. Journal of Physics: Conference Series, p. 1402: 022093.
ChemSpider. 2019. 3,4-dimethoxychalcone. Available at: url: http://www.chemspider.com/Chemical-Structure.4510680.html?rid=f1f6ec7c-f17f-4fd6-9de6-f1440f076ca6
Dewi, R. and Anwar, E. 2014. Uji Stabilitas Fisik Formula Krim yang Mengandung Ekstrak Kacang Kedelai (Glycine max). Pharmaceutical Sciences and Research, pp. 1: 194–208.
El-Badry, M. et al. 2014. Solubility and Dissolution Enhancement of Tadalafil Using Self-Nanoemulsifying Drug Delivery System. Journal of Oleo Science, pp. 63: 567–576.
Fatmasari, E. and Zulkarnain, A.K. 2021. 3,4‑dimethoxychalcone novel ultraviolet‑A protection factor in conventional sunscreen cream. JAPTR, pp. 279–284. doi:10.4103/japtr.JAPTR.
Grag, A., Anggarwal, D. and Garg, S. 2002. Spreading of Semisolid Formulations. North America: Pharmaceutical Technology, pp. 26(9): 84-105,.
Jain, P. et al. 2017. Nanostructure lipid carriers: A modish contrivance to overcome the ultraviolet effects. Egyptian Journal of Basic and Applied Sciences, pp. 4: 89–100.
Jaiswal, M., Dudhe, R. & Sharma, P.K. 2015. Nanoemulsion: an advanced mode of drug delivery system. Biotech, pp. 5:123-127.
Jiwrajka, M. et al. 2016. The Plant-Derived Chalcone 2,2′,5′-Trihydroxychalcone Provides Neuroprotection against Toll-Like Receptor 4 Triggered Inflammation in Microglia. Oxidative Medicine and Cellular Longevity, pp. 1–10.
Jumina, J. et al. 2019. Synthesis and preliminary evaluation of several chalcone derivatives as sunscreen compounds. Chemistry Journal of Moldova, 14(2), pp. 90–96. doi:10.19261/cjm.2019.624.
Mohammadi, S.M. et al. 2018. Effects of amount of excess solid, the type of stirring and sedimentation time on solubility of sodium phenytoin and lamotrigine. ADMET & DMPK, p. 10.
Osterwalder, U. and Herzog, B. 2010. The long way towards the ideal sunscreen - Where we stand and what still needs to be done. Photochemical and Photobiological Sciences, 9(4), pp. 470–481. doi:10.1039/b9pp00178f.
Rahmi, D., Yunilawati, R. & Ratnawati, E. 2013. Pengaruh Nano Pratikel Terhadap Aktifitas Antiageing pada Krim. Jurnal Sains Materi Indonesia, pp. 14 No.3: 235–238.
Ratri, S.A. 2018. Synthesis and Activity Test Of Chalcone Derivates As Broad Spectrum Sunscreen Agent And Filter Phototheraphy Agent. Universitas Gadjah Mada.
Reis Mansur, M.C.P.P. et al. 2016. In vitro and in vivo evaluation of efficacy and safety of photoprotective formulations containing antioxidant extracts. Revista Brasileira de Farmacognosia, 26(2), pp. 251–258. doi:10.1016/j.bjp.2015.11.006.
Singh, Y. et al. 2017. Nanoemulsion: Concepts, development and applications in drug delivery. Journal of Controlled Release, pp. 252: 28–49.
Sopyan, I., Gozali, D. & Paramudya, E. 2020. Formulation and Stability Testing of Griseovulfin Microemulsion. Indonesian Journal of Pharmaceutics, pp. 34–42.
Swastika, A., Mufrod & Purwanto. 2013. Antioxidant Activity of Cream Dosage Form of Tomato Extract (Solanum lycopersicum L.). Traditional Medicine Journal, pp. 18(3): 132–140.
Tou, K.A.S. et al. 2019. Influence of omega fatty acids on skin permeation of a coenzyme Q10 nanoemulsion cream formulation: characterization, in silico and ex vivo determination. Drug Development and Industrial Pharmacy, pp. 45: 1451–1458.
Wasitaatmadja, S. 1997. Penuntun Ilmu Kosmetik Medik. Jakarta: UI Press.
Winter, E., Pizzol, C., Locatelli, C., et al. 2014. In-vitro and in-vivo Effects of Free and Chalcones-Loaded Nanoemulsions: Insights and Challenges in Targeted Cancer Chemotherapies. International Journal of Environmental Research and Public Health, pp. 11: 10016–10035.
Zainol, N., Ming, T. & Darwis, Y. 2015. Development and characterization of cinnamon leaf oil nanocream for topical application. Indian Journal of Pharmaceutical Sciences, p. 77: 422.
Published
2023-02-22
How to Cite
fatmasari, erlina. (2023). Optimation of Nanocream 3,4-dimethoxychalcone as UVA Protection Agent Used Simplex Lattice Design Method. Health Media, 4(1), 12-21. https://doi.org/10.55756/hm.v4i1.127
Issue
Section
Articles
